Effect of LY487379 (3 μM) on the saturation binding of ([35S]GTPγS) or [3H]DCG-IV to native group II mGlu receptors in rat cortical membranes
The Kd values are expressed as the geometric mean (lower-upper S.E.) and the Bmax as mean ± S.E.M. from data obtained from three independent experiments.
| LY487379 | Kd | Bmax | |
|---|---|---|---|
| μM | nM | fmol/mg of protein | |
| [35S]GTPγS | 0(control) | 0.4(0.2−0.9) | 2360 ± 330 |
| 3 | 0.6(0.34−0.9) | 4,110 ± 150* | |
| [3H]DCG-IV | 0(control) | 214 (188−242) | 1326 ± 90 |
| 3 | 115 (87−150)* | 1304 ± 95 |
↵* Significantly different from control (p < 0.05, Student t test).