EC50 and Emax values for agonist-stimulated 86Rb+ efflux in NGF-treated cells
Data are derived from the curves shown in Fig. 8 and are presented as the mean ± S.E.M. from three independent experiments.
| Drug | EC50 | Emax |
|---|---|---|
| μM | % of Basal | |
| Epibatidine | 0.03 ± 0.003 | 311 ± 37 |
| A-85380 | 7.0 ± 1.2 | 260 ± 5 |
| DMPP | 32 ± 17.1 | 125 ± 10a |
| Nicotine | 33 ± 1.5 | 232 ± 23 |
| Cytisine | 42 ± 8.6 | 256 ± 21 |
| Acetylcholine | 118 ± 23 | 307 ± 24 |
| Carbachol | 379 ± 119 | 238 ± 43 |
↵ a Emax for DMPP is significantly less than that for acetylcholine (p < 0.01).