TABLE 1

Ki values of Ki16425

The Ki values were estimated from inositol phosphate response shown in Fig. 2 (left column) or from the GTPγS binding assay shown in Fig. 3 (right column), in a manner similar to that for the inositol phosphate response for LPA2 and based on the Schild regressions for other receptor subtypes. See more detail under Materials and Methods.

IP Response GTPγS Binding
μM
Receptor types
Mouse LPA1 0.34 0.25
Human LPA1 0.25
Human LPA2 6.50 5.60
Human LPA3 0.93 0.36