IC50 values for inhibition of peak and late whole-cell currents induced by 10 μM ACh during its co-application with either PhTX-343 or PhTX-(12) at +50, −25, −50, and −100 mV
For all comparisons of peak and late currents, VH values, or PhTX-343 and PhTX-(12), P < 0.0001 (unpaired Student's t test). Values are presented as mean ± S.E.M. (n cells).
| +50 mV | −25 mV | −50 mV | −100 mV | |
|---|---|---|---|---|
| μM | ||||
| PhTX-343 | ||||
| Peak current | 774 ± 139 (16) | 333 ± 32 (45) | 124 ± 7 (48) | |
| Late current | 200 ± 14 (16) | 120 ± 7 (45) | 17.2 ± 0.3 (48) | |
| PhTX-(12) | ||||
| Peak current | 70.5 ± 2.8 (21) | 46.9 ± 5.4 (22) | 49.7 ± 2.8 (43) | 28.2 ± 1.9 (45) |
| Late current | 1.37 ± 0.12 (21) | 1.67 ± 0.14 (22) | 1.16 ± 0.06 (43) | 0.77 ± 0.05 (45) |