Recovery from inhibition by co-applied 100 μM PhTX-343 or 100 μM PhTX-(12) of whole-cell currents induced by 10 μM ACh at + 50, −50, and −100 mV.
All P values are from unpaired Student's t test. Values are presented as mean ± S.E.M. (n cells).
| Toxin | Recovery | ||
|---|---|---|---|
| +50 mV | −50 mV | −100 mV | |
| % | |||
| PhTX-343 (100 μM) | |||
| Peak current | 78.6 ± 3.8 (48) | 66.6 ± 4.4 (46)* | |
| Late current | 80.3 ± 3.2 (48) | 78.3 ± 2.8 (46)† | |
| PhTX-(12) (100 μM) | |||
| Peak current | 87.1 ± 5.8 (11) | 74.2 ± 3.9 (26) | 53.3 ± 3.9 (23)*** |
| Late current | 86.8 ± 5.6 (11)** | 64.4 ± 4.0 (26) | 48.5 ± 4.2 (23)** |