TABLE 5

Single-channel parameters for currents induced by 1 μM ACh in outside-out patches obtained in the absence (control) and presence (toxin) of 10 μM PhTX-343 or 1 μM PhTX-(12)

Pomomo G
ms ms pS
PhTX-343 (n = 11)
Control 0.048 ± 0.014 4.42 ± 0.44 178 ± 38 35.7 ± 0.9
Toxin 0.018 ± 0.006** 1.58 ± 0.10*** 225 ± 55 33.5 ± 0.9
PhTX-(12) (n = 9)
Control 0.034 ± 0.012 4.40 ± 0.46 200 ± 45 35.9 ± 1.1
Toxin 0.017 ± 0.008** 4.14 ± 0.45 586 ± 145* 35.6 ± 1.1

  • ↵* (P < 0.05)

  • ↵** (P < 0.01)

  • ↵*** (P < 0.001) indicate significance of difference from control values (paired Student's t test).