TABLE 1

Low Km ALDH activity is markedly inhibited in hepatic mitochondria from GTN-tolerant rats

ALDH activity was measured at low- and high-substrate concentration in hepatic mitochondria prepared from naïve and GTN-tolerant animals. Values represent the mean ± S.D. (n = 6).

Sample [PRO] Specific Activity
mM nmol/min/mg of protein
Control 0.05 11.5 ± 5.5
Control 5.0 33.0 ± 7.8
Tolerant 0.05 1.6 ± 0.3*
Tolerant 5.0 13.9 ± 1.5*
  • PRO, propionaldehyde.

  • * P < 0.05 versus control, Student's t test for unpaired data