Cu2+ sensitivity of α subtype-mutated chimeric GABAA receptors
| Receptor (αxβ3γ2L) | Max Inhibition | IC50 | nH | n |
|---|---|---|---|---|
| % | μM | |||
| α6/α1/α6(125/126;232/231)(H141R) | 23.3 ± 2.3 | 3.8 ± 0.5 | —4.0 ± 0.3 | 3 |
| α1/α6/α1(126/125;231/232)(R140H) | 29.0 ± 4.5 | 2.9 ± 0.4 | —2.8 ± 0.6 | 5 |
| α6/α1/α6(125/126;232/231)(V134I/R135N) | 43 | 2.3 | —2.8 | 1 |
| α6/α1/α6(125/126;232/231)(V134I/R135N/H141R) | 17.8 ± 2.1 | 2.9 ± 0.2 | —2.5 ± 0.2 | 5 |
| α1/α6/α1(126/125;231/232)(I133V/N134R/R140H) | 41.4 ± 4.2 | 5 |