Compound | Rat-wt | Mouse-wt | S175P | Y188F | S277G | S290N | S175P/Y188F | Y188F/S277G | Y188F/S290N | S277G/S290N | Y188F/S277G/S290N | S175P/Y188F/S277G/S290N | Rat F188Y |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-HT | 7.10 ± 0.07 | 7.02 ± 0.04 | 6.95 ± 0.19 | 7.17 ± 0.04 | 6.77 ± 0.04 | 7.35 ± 0.27 | 7.18 ± 0.19 | 7.10 ± 0.07 | 7.18 ± 0.03 | 7.30 ± 0.15 | 6.96 ± 0.07 | 7.28 ± 0.01 | 7.44 ± 0.03 |
LSD | 8.58 ± 0.03 | 8.55 ± 0.03 | 8.67 ± 0.03 | 8.67 ± 0.09 | 8.72 ± 0.04 | 8.77 ± 0.05 | 8.71 ± 0.03 | 8.61 ± 0.02 | 8.73 ± 0.04 | 8.60 ± 0.01 | 8.82 ± 0.01 | 8.74 ± 0.04 | 8.62 ± 0.02 |
Methiothepin | 8.98 ± 0.13 | 9.25 ± 0.06 | 9.09 ± 0.06 | 9.23 ± 0.05 | 9.27 ± 0.09 | 9.01 ± 0.11 | 9.18 ± 0.01 | 9.15 ± 0.05 | 8.77 ± 0.08 | 9.02 ± 0.07 | 8.56 ± 0.17 | 8.75 ± 0.07 | 8.95 ± 0.05 |
Mianserin | 7.40 ± 0.20 | 8.49 ± 0.08 | 8.34 ± 0.11 | 8.48 ± 0.15 | 8.10 ± 0.12 | 7.59 ± 0.17 | 8.31 ± 0.01 | 7.79 ± 0.21 | 7.60 ± 0.06 | 7.47 ± 0.10 | 7.36 ± 0.05 | 7.31 ± 0.03 | 7.39 ± 0.05 |
SB-258510 | 9.12 ± 0.08 | 9.00 ± 0.04 | 8.67 ± 0.05 | 9.02 ± 0.06 | 9.07 ± 0.14 | 9.07 ± 0.22 | 8.84 ± 0.19 | 9.12 ± 0.16 | 8.98 ± 0.05 | 8.90 ± 0.05 | 9.29 ± 0.17 | 9.07 ± 0.07 | 8.66 ± 0.09 |
SB-271046 | 9.15 ± 0.02 | 8.91 ± 0.02 | 8.55 ± 0.12 | 9.32 ± 0.07 | 8.57 ± 0.19 | 8.97 ± 0.11 | 8.94 ± 0.14 | 9.19 ± 0.24 | 9.05 ± 0.15 | 8.81 ± 0.12 | 9.13 ± 0.18 | 9.16 ± 0.05 | 8.57 ± 0.07 |
SB-357134 | 8.85 ± 0.08 | 7.21 ± 0.04 | 7.00 ± 0.06 | 8.64 ± 0.14 | 7.27 ± 0.08 | 7.42 ± 0.18 | 8.41 ± 0.02 | 8.66 ± 0.12 | 8.89 ± 0.29 | 7.43 ± 0.07 | 8.47 ± 0.20 | 8.59 ± 0.05 | 7.13 ± 0.02 |
SB-258585 | 8.64 ± 0.07 | 7.95 ± 0.05 | 7.75 ± 0.03 | 8.55 ± 0.10 | 8.01 ± 0.07 | 8.10 ± 0.16 | 8.35 ± 0.10 | 8.52 ± 0.20 | 8.76 ± 0.06 | 8.09 ± 0.03 | 8.62 ± 0.06 | 8.82 ± 0.09 | 7.99 ± 0.07 |
Ro 04-6790 | 7.54 ± 0.05 | <4 | <4 | 6.35 ± 0.12 | <4 | 5.75 ± 0.17 | 6.14 ± 0.09 | 6.32 ± 0.07 | 7.14 ± 0.05 | 5.59 ± 0.17 | 7.23 ± 0.04 | 7.34 ± 0.03 | <4 |