TABLE 1

Tissue specificity for the effect of estren compared with the effect of 17β-estradiol on uterine weight, gonadal fat weight, thymus weight, trabecular BMD, and cortical BMC

Eleven-month-old female mice were ovariectomized and then treated for 4 weeks with vehicle, 17β-estradiol, or estren (n = 8). Values for the effect of estren compared with the effect of 17β-estradiol are given as the effect of estren divided by the effect of 17β-estradiol and are expressed as a percentage (equal to the percentage of estrogenic activity of estren) and as the relative tissue specificity for the estrogenic activity of estren when the effect on uterus is given as 1 (equal to the relative tissue specificity of estren).