TABLE 2

log Kd values for ICI 118551 and (±)-propranolol as antagonists of “β -blocker”-stimulated cAMP accumulation and CRE-mediated gene transcription

β-Blockers [3H]cAMP Accumulation n CRE Gene Transcription (SPAP) n
log Kd ICI 118551
Labetolol −9.59 ± 0.03 5 −9.84 ± 0.07 8
Acebutolol N.D. −9.99 ± 0.11 5
Pindolol N.D. −9.69 ± 0.05 5
Alprenolol N.D. −9.63 ± 0.06 3
(±)-Propranolol Inverse agonista 7 −9.88 ± 0.11 3
log Kd (±)-Propranolol
Labetolol −9.11 ± 0.18 3 −9.43 ± 0.11 3
Alprenolol N.D. −9.58 ± 0.25 3
  • N.D., not determined (because of the small size of the agonist response).

  • a Inverse agonist effect of propranolol precludes an ICI118551 Kd estimate.