GABA EC50 and Hill Coefficient, nH, for wild type and the Cys mutants Data are presented as mean ± S.E.M.; n is number of oocytes.
| EC50 | nH | n | |
|---|---|---|---|
| μM | |||
| Wild type | 1.67 ± 0.49 | 1.17 ± 0.10 | 4 |
| α1β2M286Cγ2s | 15.07 ± 1.52 | 1.215 ± 0.02 | 4 |
| α1A291C β2γ2s | 2.78 ± 0.29 | 1.13 ± 0.09 | 3 |
| α1S270C β2γ2s | 2.70 ± 0.72 | 1.23 ± 0.08 | 11 |
| α1β2N265Cγ2s | 6.31 ± 0.94 | 0.87 ± 0.03 | 8 |