TABLE 1

Morphine-induced down-regulation (>2-fold) of gene expression in blood leukocytes

Oligonucleotide array analysis (Affymetrix U34) of gene expression patterns in rat blood leukocytes 2 h after treatment with morphine (20 mg/kg). Samples were pooled from each treatment group. Values represent differences in expression in morphine animals compared with saline-injected control animals and are the average of two separate experiments.