TABLE 1

Structures of mutant prokineticins

Name Structure
A1MPK1 Substitute alanine 1 of PK1 with methionine
MetPK1 Add a methionine to the N terminus of PK1
Ala6PK1 Mutate the N-terminal AVITGA of PK1 to AAAAAA
delAPK1 Delete the alanine 1 of PK1
C18SPK1 Substitute cysteine 18 of PK1 with serine
C60RPK1 Substitute cysteine 60 of PK1 with arginine
AVITGA-colipase Fuse AVITGA to the residue 34-112 of human colipase
AVITGA-DKK4 Fuse AVITGA to the residue 145-224 of human dickkopf-4
Peptide 1 AVITGA
Peptide 2 AVITGACERDVQ
Chimera 12 Chimera of PK1 (1-47) and PK2 (48-81).
Chimera 21 Chimera of PK2 (1-47) and PK1 (48-86).
PK2 insert PK2 containing 21 amino acids being inserted between the residue 47 and residue 48