TABLE 3

Antagonistic potency of MetPK1 and A1MPK1 Data are shown as average ± S.E. of at least three independent experiments done in duplicate. The procedure is described in the legend to Fig. 5. The potency increase (-fold) after preincubation is shown in parentheses below the IC₅₀ values.

	IC₅₀ without Preincubation				IC₅₀ with Preincubation
Antagonists	PKR1		PKR2		PKR1		PKR2
	PK1	PK2	PK1	PK2	PK1	PK2	PK1	PK2
		nM				nM
MetPK1	27 ± 4.54	98 ± 4.4	36.4 ± 4.56	42.7 ± 3.52	10.2 ± 4.63	29.98 ± 6.66	3.6 ± 1.29	4.49 ± 0.54
					(2.6)	(3.3)	(10.1)	(9.5)
A1MPK1	27.6 ± 5.03	208 ± 83.75	40.7 ± 6.5	116 ± 91.53	16.1 ± 2.89	32.8 ± 2.6	8.2 ± 2.61	7.9 ± 5.59
					(1.7)	(6.3)	(5.0)	(14.7)