TABLE 5

A comparison of 125I-α-conotoxin MII binding in three thalamic areas of control rats and mice The thalamic cuts (see Materials and Methods) were further sectioned into approximately 10% of the lateral thalamic, 60% of the dorsal thalamic, and 30% of the subthalamic material. The binding of 125I-Cntx to particulates (total and nonspecific; n = 6 for each) was performed as described in Table 4. The results are expressed as fmol 125I-Cntx specifically bound per mg particulate protein. The binding to rat particulates was for each area significantly higher (*, p < 0.05 in t tests) than in the corresponding mouse particulates. The binding to particulates from dorsal hypothalamic area was in both species significantly larger (†, p < 0.05 in t tests) than that for the other two areas of the species.

Animal Dorsal Thalamic Area Subthalamic Area Lateral Thalamic Area
Rat 6.3 ± 0.32* 4.6 ± 0.13* 4.1 ± 0.38*
Mouse 4.3 ± 0.22 † 2.2 ± 0.24 2.6 ± 0.24