Changes in hepatic GSH and cysteine levels and GSH synthesis rates in hepatocyte RXRα-deficient mice Results represent mean ± S.D. from three to five animals in each group. Hepatic GSH and cysteine levels and GSH synthesis rates were determined as described under Materials and Methods.
| Hepatic Levels | RXRα +/+ | RXRα -/- |
|---|---|---|
| GSH (nmol/mg of protein) | 35.84 ± 2.05 | 19.65 ± 1.88a |
| Cysteine (nmol/mg of protein) | 1.70 ± 0.13 | 1.38 ± 0.11 |
| GSH synthesis rate (nmol/mg/min) | 2.45 ± 0.36 | 1.51 ± 0.13a |
↵ a P < 0.05 versus wild-type controls by unpaired t test