Mutant | Lqh-3 | LqhαIT | Lqh-2 |
---|---|---|---|
nM | |||
rNaV1.4, wt | 1.83 ± 0.25 | 1.19 ± 0.24 | 1.64 ± 0.16 |
NaV1.2 (NaV1.1) | 1840 ± 173 | 20.6 ± 0.9 | 0.969 ± 0.071 |
hNaV1.3 (rNaV1.7) | 3890 ± 1110 | 190 ± 11 | 2.35 ± 0.29 |
NaV1.6 | 9.48 ± 0.82 | 0.247 ± 0.041 | 0.778 ± 0.058 |
hNaV1.7 | 6.22 ± 0.64 | 50.8 ± 5.2 | 7.00 ± 1.15 |
NaV1.4_DtoE | 2980 ± 282 | 65.7 ± 6.1 | 1.92 ± 0.23 |
NaV1.2_EtoD | 5.52 ± 0.56 | 0.338 ± 0.028 | 0.53 ± 0.08 |
NaV1.7_DtoE | 2290 ± 220 | 42.1 ± 4.0 | 1.56 ± 0.15 |
NaV1.4_QtoE | 2.59 ± 0.89 | 1.80 ± 0.25 | 13.2 ± 1.1 |
NaV1.4_KtoT | 7.46 ± 1.21 | 96.1 ± 7.9 | 26.2 ± 2.7 |
NaV1.4_LA-StoMF-A | 2.88 ± 0.22 | 0.934 ± 0.169 | 0.804 ± 0.054 |