Mutation in hA2B Receptor | Constitutively Active Mutation of Equivalent Amino Acid | Literature Reference |
---|---|---|
T42A | M71K in mMC1 | Vage et al. (1999) |
M73K in sMC1 | Vage et al. (1999) | |
V54L | L91D in viral KSHVa | Rosenkilde et al. (2000) |
S95G | L126A in hC5a | Baranski et al. (1999) |
V240M | I630L in hTSH | Tonacchera et al. (1998) |
I242T | T577I in hLHCG | Kosugi et al. (1995) |
T632I in hTSH | Porcellini et al. (1994) | |
V250M | Y282F in mTRHR | Colson et al. (1998) |
Y282A in mTRHR | Colson et al. (1998) | |
N254Y | M292L in rα1A | Hwa and Perez (1996) |
V284A | C672Y in hTSH | Duprez et al. (1994) |
h, human; m, mouse; s, sheep; r, rat; C5a anaphylatoxin receptor; KSHV, Karposi's sarcoma-associated herpes virus; LHCG, lutropin-choriogonadotropin hormone receptor; MC1, melanocortin-1 receptor; TRHR, thyrotropin-releasing hormone receptor; TSH, thyrotropin receptor.
↵ a wt receptor is constitutively active, mutant is not