Effect of SEA (0.1 μM) on steady-state inward currents mediated by NCX1.1 and mutant Na+-Ca2+ exchangers
| Exchanger Type | Iss (% Inhibition) | n |
|---|---|---|
| 3 μM Ca2+ | ||
| WT | 3 ± 1 | 6 |
| F223E | 52 ± 4* | 6 |
| K225Q | 15 ± 5 | 10 |
| Δ229-232 | 13 ± 3* | 4 |
| K229Q | 5 ± 2 | 12 |
| 10 μM Ca2+ | ||
| WT | 3 ± 1 | 15 |
| F223E | 28 ± 5* | 10 |
| K225Q | 10 ± 5 | 8 |
| Δ229-232 | 2 ± 1 | 8 |
| K229Q | 7 ± 2 | 10 |
Iss, steady-state inward current; WT, wild-type NCX1.1.
↵* P < 0.05 compared with wild type