Physiological conditions in the presence or absence of DPH-067517 after MCA occlusion
DPH-067517 (3 mg/kg, i.p.) or saline was administrated 15 min before and 6 h after MCAO as described under Materials and Methods. Physiological data were measured before (15 min before MCAO), 15 min after, and 6 h after MCAO. No statistical difference was observed for these physiological parameters between DPH-067517 and saline treatment.
| Treatment | CBF (n = 8) | HR (n = 8) | MABP (n = 8) | pCO2 (n = 9) | pO2 (n = 9) | pH (n = 9) |
|---|---|---|---|---|---|---|
| % | min−1 | mm Hg | mm Hg | mm Hg | ||
| Saline | ||||||
| Before | 100 | 309 ± 12 | 92 ± 5 | 43 ± 3 | 131 ± 9 | 7.28 |
| 15 min after | 28+6 | 317 ± 15 | 85 ± 7 | 47 ± 5 | 133 ± 10 | 7.23 |
| 6 h after | 85+8 | 314 ± 24 | 97 ± 9 | 45 ± 4 | 134 ± 12 | 7.31 |
| DPH-067517 | ||||||
| Before | 100 | 311 ± 10 | 91 ± 3 | 43 ± 2 | 132 ± 10 | 7.30 |
| 15 min after | 29+4 | 298 ± 12 | 84 ± 6 | 46 ± 4 | 126 ± 11 | 7.22 |
| 6 h after | 88+6 | 308 ± 19 | 95 ± 6 | 44 ± 5 | 135 ± 13 | 7.27 |
CBF, cerebral blood flow (shown as a percentage of the CBF level before MCAO); HR, heart rate; MABP, mean arterial blood pressure.