Treatment Groups | ||||
---|---|---|---|---|
L-742694 | DEX | |||
Gene | Liver | Small Intestine | Liver | Small Intestine |
CYP3A1/23 | 96.9 ± 31.4 | 0.60 ± 0.10 | 420 ± 76.6 | 0.11 ± 0.03 |
CYP3A9 | 0.99 ± 0.20 | 0.74 ± 0.19 | 0.78 ± 0.27 | 2.68 ± 0.58 |
CYP3A18 | 11.3 ± 4.01 | 0.42 ± 0.05 | 19.2 ± 3.20 | 0.50 ± 0.08 |
UGT1A1 | 2.92 ± 0.40 | 0.54 ± 0.09 | 3.89 ± 0.30 | 0.29 ± 0.06 |
UGT2B1 | 2.70 ± 0.47 | 0.23 ± 0.14 | 6.12 ± 2.01 | 0.05 ± 0.01 |
SULT1A1 | 0.34 ± 0.05 | 0.21 ± 0.09 | 1.22 ± 0.25 | 2.48 ± 0.16 |
Mrp2 | 0.52 ± 0.06 | 1.04 ± 0.12 | 0.28 ± 0.04 | 0.52 ± 0.11 |
Mrp3 | 12.6 ± 0.99 | 0.45 ± 0.21 | 0.62 ± 0.16 | 0.09 ± 0.002 |
Oatp2 | 2.68 ± 0.41 | 0.54 ± 0.26 | 3.62 ± 0.21 | 0.07 ± 0.01 |
PXR | 1.15 ± 0.19 | 0.99 ± 0.19 | 1.25 ± 0.21 | 1.01 ± 0.28 |
CAR | 1.26 ± 0.33 | 0.98 ± 0.20 | 1.14 ± 0.40 | 0.98 ± 0.20 |