Comparison of oral BaP for 18 days: effects on body weight and spleen and thymus weights in Cyp1a1(−/−) versus Cyp1a1(+/+) mice
Values in all tables are expressed as means + S.E.M. Note that the same group of control animals was used for comparison with the three BaP doses. Both BaP-treated groups contained 12 mice; both control groups contained six mice. Any comparison with a P value > 0.05 is not denoted.
| Cyp1a1(−/−) | Cyp1a1(+/+) | |||
|---|---|---|---|---|
| BaP | Control | BaP | Control | |
| Oral BaP, 125 mg/kg/day | ||||
| Body weight gain or loss (g) | −5.2 ± 0.2 | 3.4 ± 0.5 | 2.4 ± 0.3 | 2.6 ± 0.4 |
| P < 0.0001a,b,c | ||||
| Spleen weight (mg/g body wt.) | 0.5 ± 0.1 | 3.5 ± 0.1 | 2.6 ± 0.1 | 3.0 ± 0.2 |
| P < 0.0001a,b,c | P = 0.002b | |||
| Thymus weight (mg/g body wt.) | 0.3 ± 0.0 | 3.3 ± 0.3 | 2.0 ± 0.2 | 2.8 ± 0.2 |
| P < 0.0001a,b,c | P = 0.026a | |||
| P = 0.007b | ||||
| Oral BaP, 12.5 mg/kg/day | ||||
| Body weight gain or loss (g) | 0.7 ± 0.5 | 3.4 ± 0.5 | 2.6 ± 0.3 | 2.6 ± 0.4 |
| P = 0.003a | ||||
| P = 0.011b | ||||
| P = 0.0026c | ||||
| Spleen weight (mg/g body wt.) | 2.4 ± 0.2 | 3.5 ± 0.1 | 2.6 ± 0.1 | 3.0 ± 0.3 |
| P = 0.001a | ||||
| Thymus weight (mg/g body wt.) | 1.6 ± 0.3 | 3.3 ± 0.3 | 3.0 ± 0.4 | 2.8 ± 0.2 |
| P = 0.012a | ||||
| P = 0.034b | ||||
| P = 0.02c | ||||
| Oral BaP, 1.25 mg/kg/day | ||||
| Body weight gain or loss (g) | 1.2 ± 0.5 | 3.4 ± 0.5 | 2.7 ± 0.3 | 2.6 ± 0.4 |
| P = 0.007a | ||||
| P = 0.034b | ||||
| P = 0.03c | ||||
| Spleen weight (mg/g body wt.) | 3.1 ± 0.2 | 3.5 ± 0.1 | 3.1 ± 0.1 | 3.0 ± 0.2 |
| Thymus weight (mg/g body wt.) | 2.9 ± 0.3 | 3.3 ± 0.3 | 2.8 ± 0.5 | 2.8 ± 0.2 |