Ki values for the sulfonamide analogs with hiCE, hCE1, hAcChE, hBuChE, and rCE
o-NPA was used as a substrate with the CEs, and acetylthiocholine and butyrylthiocholine were used for hAcChE and hBuChE, respectively.
| ID | hiCE Ki ± SE | hCE1 Ki ± SE | hAcChE Ki | hBuChE Ki | rCE Ki ± SE | Ratio hCE1 Ki/hiCE Ki |
|---|---|---|---|---|---|---|
| nM | ||||||
| 1 | 53.3 ± 5.5 | 13,700 ± 4870 | >100,000 | >100,000 | 1200 ± 230 | >250 |
| 2 | 451 ± 39 | >100,000 | >100,000 | >100,000 | >100,000 | >220 |
| 3 | 218 ± 45 | >100,000 | >100,000 | >100,000 | >100,000 | >450 |
| 4 | 194 ± 23 | >100,000 | >100,000 | >100,000 | >100,000 | >510 |
| 5 | 165 ± 33 | >100,000 | >100,000 | >100,000 | 319 ± 37 | >250 |
| 6 | 365 ± 87 | >100,000 | >100,000 | >100,000 | 3230 ± 439 | >600 |
| 7 | 767 ± 285 | >100,000 | >100,000 | >100,000 | 739 ± 384 | >130 |
| 8 | 1060 ± 133 | >100,000 | >100,000 | >100,000 | 1550 ± 350 | >90 |
| 9 | 1310 ± 176 | >100,000 | >100,000 | >100,000 | 2000 ± 755 | >75 |