TABLE 1
Sequence and composition of ISIS 25291 and mismatch control oligonucleotides Each oligonucleotide is composed of a 10-base phosphorothioate modified 2′deoxy domain positioned in the center, flanked by two 4-base 2′-MOE phosphodiester modified domains on the 5′ and 3′ ends. 2′-MOE modified nucleotides are indicated by underline, all cytosine residues are methylated at the five position, and mismatch bases are indicated in bold.