TABLE 4

Quantitative measurements of CAM growth from days 4 to 5, vessel lengths, and vein diameter in the early CAM assay

JNJ-17029259 Dose	CAM Growth	Vein Length^b	Artery Length^c	Vein Diameter^d
		%
DMSO Only	100.0 ± 0.0	100.0 ± 0.0	100.0 ± 0.0	100.0 ± 0.0
5 nM	103.5 ± 20.1	97.8 ± 13.8	101.7 ± 25.7	107.7 ± 25.1
10 nM	97.4 ± 9.7	126.2 ± 15.9	97.3 ± 24.4	108.8 ± 13.1
20 nM	80.1 ± 16.1	29.5 ± 13.7^a	30.2 ± 12.2^a	34.4 ± 10.6^a
30 nM	67.9 ± 13.0	34.6 ± 25.4^a	16.1 ± 6.3^a	47.9 ± 16.0^a
40 nM	79.2 ± 14.2	33.3 ± 18.8^a	28.8 ± 15.9^a	30.5 ± 14.8^a
50 nM	56.7 ± 11.2	32.2 ± 22.4^a	11.7 ± 8.2^a	26.4 ± 18.5^a

↵ a P < 0.05 vs. DMSO using ANOVA on ranks followed by a Student-Newman-Keuls method of multiple comparisons.
↵ b IC₅₀ = 15.8 nM.
↵ c IC₅₀ = 17.6 nM.
↵ d IC₅₀ = 16.9 nM.