Vinflunine increases mitotic index and inhibits metaphase to anaphase transition
Results are expressed as mean ± S.D. (counting of 1000 cells per condition).
| Mitotic Index | Anaphase/Metaphase ratio | |||
|---|---|---|---|---|
| 6 h | 12 h | 24 h | 24 h | |
| % | ||||
| Control | 3.7 ± 0.5 | 4.2 ± 0.5 | 4.3 ± 0.8 | 0.19 ± 0.02 |
| IC50 | 6.3 ± 2.4 | 6.8 ± 1.5 | 6.2 ± 0.9 | 0.12 ± 0.04* |
| IC70 | 7.1 ± 1.6 | 9.8 ± 2.6 | 9.8 ± 1.8* | 0.03 ± 0.01* |
| 500 nM | 9.4 ± 3.5* | 28 ± 4.2** | 40.6 ± 1.0** | 0.00 ± 0.00* |