TABLE 2

Parameters used for the fitting of the concentration-response relationships of nicorandil-induced activation of SUR2x/Kir6.2 channels The effect of nicorandil on the K_ATP channels containing SUR2x with or without D834N (D1N) plus E1471Q (E2Q) mutations was measured in the presence of the internal solution B or C containing 1 mM ATP. The concentration-response relationships were fit with eq. 3 with the following parameters.

	Type of Internal Solution			SUR Type	a	b	K_1/2	h
	[K⁺]^a	[Na⁺]^a	[Mg²⁺]^a	SUR Type	a	b	K_1/2	h
							mM
C	80	60	0	SUR2A(D1N,E2Q)	0.12	0.56	0.17	0.55
				SUR2A(Wt)	0.01	0.14	0.98	1.52
				SUR2B(D1N,E2Q)	0.19	0.69	0.34	0.41
				SUR2B(Wt)	0.03	0.11	0.57	0.78
B	140	0	0	SUR2A(D1N,E2Q)	0.02	0.50	2.95	0.65
				SUR2A(Wt)	0.02	0.73	8.64	0.45
				SUR2B(D1N,E2Q)	0.04	0.37	1.09	0.65
				SUR2B(Wt)	0.04	0.40	1.12	0.49