TABLE 1
Activation parameters of WT, WT + A561P, WT + A561T, and WT + A561V HERG currents Voltage protocol was the same as described in Fig 3C. Tail currents were fitted using a Boltzmann equation: Itail/Itail max = 1/{1 + exp[-(Vpp - V1/2)/k]}, where Itail max is peak Itail, Vpp is the prepulse potential, V1/2 is the prepulse voltage for which Itail is half of Itail max, and k is the slope factor. WT was tested versus data obtained when PEI was used as transfection vector (see clobutinol experiments) and WT + A561s versus WT.