TRH-R1 | Ki | |
---|---|---|
TRH | Midazolam | |
μM | ||
Wild type | 0.009 | 0.026 |
(0.007–0.012) | (0.020–0.036) | |
N110A | 0.035 | 3.07 |
(0.03–0.04) | (2.30–4.08) | |
Y282F | 0.09 | 0.05 |
(0.07–0.11) | (0.03–0.08) | |
R306K | 0.017 | 0.23 |
(0.013–0.021) | (0.15–0.34) | |
F199A | 0.16 | 0.37 |
(0.13–0.18) | (0.27–0.50) | |
W279A | 0.007 | 0.55 |
(0.006–0.008) | (0.41–0.75) | |
W279F | 0.0016 | 0.11 |
(0.0014–0.0018) | (0.09–0.14) | |
W279H | 0.0015 | 0.11 |
(0.0013–0.0018) | (0.09–0.12) |