Emax and EC50 values of agonist inhibition of forskolin-stimulated adenylyl cyclase activity in cerebellum Data are mean values ± S.E.M. obtained from nonlinear regression analyses of the data shown in Figs. 5 and 6.
| Drug | Treatment | Emax | EC50 |
|---|---|---|---|
| % of inhibition | nM | ||
| WIN 55,212-2 | Vehicle | 33 ± 2.0 | 1432 ± 386 |
| THC | 32 ± 4.1 | 2705 ± 254* | |
| CP 55,940 | Vehicle | 38 ± 1.6 | 44 ± 17 |
| THC | 30 ± 1.4* | 112 ± 43 | |
| THC | Vehicle | 24 ± 3.3 | 654 ± 228 |
| THC | 14 ± 1.4* | 797 ± 290 | |
| PIA | Vehicle | 48 ± 2.6 | 141 ± 19 |
| THC | 39 ± 2.6* | 147 ± 28 | |
| Baclofen | Vehicle | 49 ± 2.6 | 2978 ± 818 |
| THC | 40 ± 1.8* | 5361 ± 613 |
↵* , p < 0.05; different from vehicle-treated mice