Ligand | KI | |
---|---|---|
Wild-Type | H452Y | |
nM | ||
5-HT | 259.2 ± 57.7 | 256.0 ± 26.2 |
DOI | 14.7 ± 0.8 | 17.3 ± 2.9 |
LSD | 0.18 ± 0.01 | 0.18 ± 0.02 |
Amitriptyline | 55.6 ± 9.1 | 59.4 ± 3.1 |
Clozapine | 11.2 ± 2.4 | 11.9 ± 1.0 |
[3H]Ketanserin | 1.7 ± 0.2 | 1.4 ± 0.2 |
MDL-100,907 | 0.13 ± 0.02 | 0.17 ± 0.01 |
2-Bromo-LSD | 1.8 ± 0.3 | 1.4 ± 0.2 |
DOI, (±)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane.