Residual folate-DTPA-111In in tumor as a function of time after administration of conjugate (2000 nmol/kg) at hour 0
Tumor-bearing mice were injected with 2000 nmol/kg of folate-DTPA-111In at time 0 and sacrificed at 8, 24, 48, 72, and 120 h. Values are presented as mean ± S.E.M. of three to four experiments (five mice per group).
| Time of Sacrifice (h) | |||||
|---|---|---|---|---|---|
| 8 | 24 | 48 | 72 | 120 | |
| % injected dose/g of tumor | |||||
| M109 | 3.28 ± 0.29 | 2.84 ± 0.31 | 1.73 ± 0.21 | 1.08 ± 0.09 | 0.4 ± 0.07 |
| Line 01 | 1.72 ± 0.32 | 1.51 ± 0.45 | 1.33 ± 0.35 | 0.69 ± 0.13 | 0.32 ± 0.07 |
| L1210A | 8.25 ± 1.48 | 7.5 ± 1.22 | 6.76 ± 0.74 | 3.85 ± 0.32 | 2.64 ± 0.64 |