TABLE 1

Ki values of KYT-1 and KYT-36 toward gingipains and other proteinases

Proteinase Ki
KYT-1 KYT-36
M
Rgp 1.3×10−10 >10−4
Kgp 2.6× 10−6 7.5×10−11
Trypsin 1.2× 10−6 1.3× 10−7
Cathepsin B 3.4× 10−8 3.7× 10−9
Cathepsin L 1.2× 10−8 7.0× 10−8
Cathepsin H 1.5× 10−4 1.6× 10−4