Parameters used to compute the mathematical model describing the inhibition and stimulation of ICl(Ca) by niflumic acid
| Units | |
|---|---|
| Permeability and selectivity | |
| PCl(Ca) max = 0.01 | μM ms-1 |
| ECl = -30 | mV |
| Values of gating variables | |
| C = 0.6 | |
| O1 = 0.7 | |
| B1 = 0 | |
| B2 = 0 | |
| O2 = 1 | |
| O3 = 1 | |
| Activation and deactivation | |
| α1 (V) = 0.0075/{1 + exp [-0.1 * (V – 50)]} | ms-1 |
| β1 (V) = 0.1 /{1 + exp [0.1 * (V + 80)]} | ms-1 |
| High-affinity binding of NFA and unbinding | |
| α2 ([NFA]) = [NFA]2/{[NFA]2 + 0.0232} | ms-1 |
| β2 = 0.5 | ms-1 |
| α3 = 0.058 | ms-1 |
| β3 ([NFA]) = 0.05*{[NFA]/{[NFA] + 0.01} | ms-1 |
| Low-affinity binding of NFA and unbinding | |
| α4 ([NFA]) = 0.00325*{[NFA]/{[NFA] + 1.25} | ms-1 |
| α5 = 0.0004 | ms-1 |
| Recovery from high affinity and fast binding of NFA | |
| α6 = 0.0006 | ms-1 |
| Recovery from low affinity and slow binding of NFA | |
| α7 = 0.0001 | ms-1 |
ECl, equilibrium potential for chloride ions.