TABLE 2
IC50 values and potentiation ratios of MMDX or MMDX incubated with dexamethasone-induced rat liver microsomes plus NADPH on human tumor cell lines and CHO cell lines that express either human P450 reductase or CYP3A4 supplemented with human P450 reductase Each IC50 value is derived from triplicate samples analyzed as shown in Figs. 3 and 4. Potentiation ratio is the IC50 of MMDX/IC50 of (MMDX + dexamethasone-induced liver microsomes).