TABLE 3
Chemosensitivities of CEM, CEM-ARAC/hENT2, CEM-ARAC/hCNT1, CEM-ARAC/hCNT2, and CEM-ARAC cells to BR and TR Actively proliferating cells were exposed to graded concentrations of BR or TR in 96-well plates for 4 and 48 h as described under Materials and Methods. In protection experiments, CEM cells were treated with 1 μM NBMPR 1 h before the addition of BR or TR in the presence of 1 μM NBMPR. IC50 values were obtained from the MTS-cytotoxicity relationships and are means of at least two experiments, each conducted with six replicates. Mean ± S.E. values were determined using GraphPad Prism software version 3.0.