Ertiprotafib and compound 3 lower glucose, insulin, triglycerides, and free fatty acids in fa/fa rats
| Rats | Treatment | Dose | Fasting Blood Glucose | Insulin | Triglycerides | Free Fatty Acids |
|---|---|---|---|---|---|---|
| mg / dl | ng / ml | mg / dl | μmol / l | |||
| Lean | 68 ± 5 | 3.7 ± 0.3 | 118 ± 11 | 640 ± 50 | ||
| fa/fa | Vehicle | 115 ± 18 | 15.8 ± 1.8 | 1060 ± 190 | 1620 ± 160 | |
| fa/fa | Ertiprotafib | 25 mg/kg | 78 ± 5* | 9.8 ± 0.7* | 260 ± 30* | 560 ± 40* |
| fa/fa | Ertiprotafib | 5 mg/kg | 99 ± 4 | 13.1 ± 1.4 | 770 ± 230 | 1160 ± 210 |
| fa/fa | Compound 3 | 25 mg/kg | 77 ± 8* | 7.3 ± 0.6* | 147 ± 18* | 450 ± 40* |
| fa/fa | Compound 3 | 5 mg/kg | 92 ± 3 | 13.6 ± 1.1 | 550 ± 70 | 870 ± 40* |
↵* p < 0.05 compared with vehicle