Extent of tissue toxicity in the Null and wild-type mice treated with acetaminophen at 400 mg/kg
Male 3-month-old wild-type and Null mice were treated with a single intraperitoneal injection of acetaminophen after overnight fasting. Histopathology of the liver, lung, OE, nasal respiratory epithelium, and LNG was examined 24 h after injection. The severity of lesions in the tissues was graded: +, moderate; ±, mild; and -, negative.
| Number of Mice in Each Grade | ||||||
|---|---|---|---|---|---|---|
| Tissues | Wild-Type | Null | ||||
| + | ± | - | + | ± | - | |
| Liver | 7 | 8 | ||||
| Kidney | 4 | 3 | 1 | 7 | ||
| Lung | 7 | 6 | 2 | |||
| Nose | ||||||
| OE | 5 | 1 | 1 | 3 | 5 | |
| Respiratory epithelium | 7 | 2 | 6 | |||
| LNG | 7 | 2 | 5 | 1 | ||