TABLE 1

Blood gases in mice

The values are expressed as the means ± S.E. of five animals. Data were obtained from mice 10 h after sham-operation or CLP. FR26330 (10 mg/kg, i.p.) was administered or NF-κB decoy ODN or its scrambled form was transfected 60 min after CLP.

	PaO₂	PaCO₂	pH	Base Excess
	mm Hg	mm Hg		mM
Sham-operated	123.0 ± 1.4	34.0 ± 0.9	7.43 ± 0.02	0.6 ± 0.5
10-h CLP	70.7 ± 3.5^*	20.5 ± 0.6^*	7.17 ± 0.02^*	−11.2 ± 0.6^*
+ FR260330	87.6 ± 3.0^*^†	28.4 ± 1.5^*^†	7.25 ± 0.02^*^†	−6.9 ± 0.6^*^†
+NF-kB decoy	109.7 ± 3.8^†	32.6 ± 0.9^†	7.35 ± 0.02^†	−9.7 ± 0.6^†
+Scrambled decoy	67.7 ± 4.7^*	21.0 ± 1.2^*	7.17 ± 0.03^*	−11.7 ± 1.0^*

↵* Significant difference from sham-operated control values.
↵† Significant difference from values obtained in CLP-induced septic mice without treatment.