TABLE 3

E_max and EC₅₀ values for various chimeric GnRHs

Data represent the mean ± S.E.M. of three independent experiments performed in duplicate.

Chimeric GnRH	gm2		rEL3L		SEP/L^7.38F/L^7.43F/A^7.46P/P^7.47C
Chimeric GnRH	E_max	EC₅₀	E_max	EC₅₀	E_max	EC₅₀
	fold induction	log M	fold induction	log M	fold induction	log M
GnRH-I	9.33 ± 0.35	−6.00 ± 0.10	6.24 ± 0.14	−8.38 ± 0.09	5.27 ± 0.13	−8.79 ± 0.11
[His⁵]GnRH-I	8.66 ± 1.11	−6.38 ± 0.34	6.82 ± 0.39	−8.51 ± 0.22	4.78 ± 0.21	−8.53 ± 0.18
[Trp⁷]GnRH-I	10.73 ± 0.05	−7.15 ± 0.05^*	3.38 ± 0.14	−9.42 ± 0.26^*	3.00 ± 0.19	−8.90 ± 0.34
[Trp⁸]GnRH-I	9.48 ± 0.11	−6.74 ± 0.03^*	4.80 ± 0.17	−8.16 ± 0.15	3.42 ± 0.20	−8.30 ± 0.24
[Trp⁷, Leu⁸]GnRH-I	12.11 ± 0.42	−7.47 ± 0.11^*	5.68 ± 0.38	−8.43 ± 0.27	5.94 ± 0.43	−7.59 ± 0.23^*