Chemical | Route | Dose | Time | Mechanism |
---|---|---|---|---|
Acetominaphen | p.o. | 400 mg/kg | 1 day | Electrophile |
TCDD | p.o. | 10 μg/kg | 2 days | AHR agonist |
3-Methylcholanthrene | i.p. | 100 mg/kg | 2 days | AHR agonist |
β-Napthoflavone | p.o. | 100 mg/kg | 2 days | AHR agonist |
Aroclor 1260 | i.p. | 200 mg/kg | 2 days | AHR agonist |
Phenobarbital | p.o. | 100 mg/kg/day | 2 days | CAR agonist |
TCPOBOP | i.p. | 3 mg/kg/day | 2 days | CAR agonist |
Circadian rhythm | None | None | 0, 4, 8, 12, 16, 24 h | Circadian |
Ketoconazole | i.p. | 250 mg/kg | 1, 4 days | P450 inducer |
Cobalt | p.o. | 60 mg/kg | 2 days | Heme disrupter |
Phenylhydrazine | p.o. | 100 mg/kg | 2 days | Heme disrupter |
DEHP | Chow | 2% | 2 weeks | PPAR agonist |
Ciprofibrate | Chow | 0.1% | 2 weeks | PPAR agonist |
Wy-14,643 | Chow | 0.1% | 2 weeks | PPAR agonist |
Corn oil | p.o. | 1 μl/g | 2 days | Vehicle |
Corn oil | i.p. | 1 μl/g | 2 days | Vehicle |
DMSO | i.p. | 1 μl/g | 2 days | Vehicle |
Saline | p.o. | 1 μl/g | 2 days | Vehicle |
Lipopolysaccharide | i.p. | 1 mg/kg | 6, 12, 24, 48 h | Inflammatory agent |
Interleukin-1β | i.p. | 25 μg/kg | 6 h | Inflammatory response |
Interleukin-6 | i.p. | 25 μg/kg | 6 h | Inflammatory response |
Tumor necrosis factor-α | i.p. | 5 g/kg | 6, 12 h | Inflammatory response |
Fasting | None | None | 1, 2 days | Metabolism |
Sex | None | None | None | Sex |
AHR, aryl hydrocarbon receptor; DEHP, diethyl-hexyl-phthalate; TCPOBOP, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene.