Description of the human data set used for subclassification of Rhodopsin GPCRs
The classification is based on Fredriksson et al. (2003c), except for OLF, which are from Zozulya et al. (2001).
| Model Name | Number of GPCRs | Description |
|---|---|---|
| AMIN (α group) | 42 | Bioamine GPCRs binding 5-hydroxytryptamine, dopamine, histamine, trace amines, adrenalin, and acetylcholine |
| MEC (α group) | 22 | Receptors for phospholipids (EDG), melanocortin, cannabinoids, and somatostatin receptors together with three orphan GPCRs |
| MTN (α group) | 3 | Melatonin and orphan receptor GPR50 |
| OPN (α group) | 9 | Opsin/putative opsin receptors and orphan receptors GPR21 and GPR52 |
| PTGR (α group) | 15 | Prostaglandin receptors and orphan receptors SREB 1-3, GPR26, GPR61, GPR62, and GPR78 |
| PEP (β group) | 35 | Receptors for NPY, tachykinins, neurotensin, orexin, neuromedin, NPFF, PrRP, GnRH, CCK, etc. |
| CHEM (γ group) | 42 | Bradykinin receptors and receptors/putative receptors for chemokines |
| MCHR (γ group) | 2 | Receptors for melanocyte concentrating hormone |
| SOG (γ group) | 15 | Somatostatin, opsin, and galanin receptors |
| LGR (δ group) | 8 | Orphan LGR receptors and receptors for relaxin, FSH, TSH, and LH |
| MRG (δ group) | 8 | MRG and MAS receptors |
| OLF (δ group) | 347 | Olfactory receptors according to Zozulya et al. (2001) |
| PUR (δ group) | 42 | Purin/putative purin receptors, formyl-peptide receptors, retinoic acid receptors, and orphan GPCRs |