TABLE 3

Sensitivity/resistance profile (EC50 values) of mutant HIV-1 strains against plant lectins and other viral entry or reverse transcriptase inhibitors

Values in brackets represent the degree (-fold) of resistance of the test compounds compared with wild-type virus.

Compound Wild-type HIV-1(IIIB) HIV-1/HHA-500CS Fold Resistance HIV-1/HHA-500SN Fold Resistance HIV-1/GNA-500CS Fold Resistance
μg/ml μg/ml μg/ml μg/ml
GNA 0.27 ± 0.058 26.7 ± 5.77 [99] 250 ± 87 [926] 157 ± 98 [581]
HHA 0.21 ± 0.12 55 ± 34 [262] 193 ± 93 [919] 103 ± 45 [490]
LOA 0.057 ± 0.021 6.2 ± 3.4 [109] 13 ± 6.1 [228] 14 ± 6.0 [246]
CA 0.43 ± 0.058 60.0 ± 34.6 [140] ≥100 [≥233] 57 ± 38 [133]
NPA 0.37 ± 0.058 71 ± 38 [192] ≥100 [≥270] ≥100 [≥270]
CV-N 0.015 ± 0.0058 0.077 ± 0.021 [5.1] 0.43 ± 0.32 [29] 0.17 ± 0.20 [11]
DS-5000 0.60 ± 0.17 0.50 ± 0.26 [0.8] 0.60 ± 0.35 [1] 0.21 ± 0.17 [0.35]
AMD3100 0.031 ± 0.020 0.057 ± 0.006 [1.8] 0.025 ± 0.013 [0.8] 0.10 ± 0.09 [3.2]
T-20 0.038 ± 0.010 0.047 ± 0.014 [1.2] 0.036 ± 0.026 [1.0] 0.053 ± 0.015 [1.4]
UC-781 0.0015 ± 0.0004 0.002 ± 0.0003 [1.3] 0.003 ± 0.0004 [2.0] 0.003 ± 0.0007 [2.0]
(R)-PMPA 1.0 ± 0.25 1.3 ± 1.2 [1.3] 4.1 ± 2.8 [4.1] 2.8 ± 0.73 [2.8]
Mab 2G12 1.4 ± 0.4 >25 [>15] >25 [>15] >25 [>15]