Compound | Wild-type HIV-1(IIIB) | HIV-1/HHA-500CS | Fold Resistance | HIV-1/HHA-500SN | Fold Resistance | HIV-1/GNA-500CS | Fold Resistance |
---|---|---|---|---|---|---|---|
μg/ml | μg/ml | μg/ml | μg/ml | ||||
GNA | 0.27 ± 0.058 | 26.7 ± 5.77 | [99] | 250 ± 87 | [926] | 157 ± 98 | [581] |
HHA | 0.21 ± 0.12 | 55 ± 34 | [262] | 193 ± 93 | [919] | 103 ± 45 | [490] |
LOA | 0.057 ± 0.021 | 6.2 ± 3.4 | [109] | 13 ± 6.1 | [228] | 14 ± 6.0 | [246] |
CA | 0.43 ± 0.058 | 60.0 ± 34.6 | [140] | ≥100 | [≥233] | 57 ± 38 | [133] |
NPA | 0.37 ± 0.058 | 71 ± 38 | [192] | ≥100 | [≥270] | ≥100 | [≥270] |
CV-N | 0.015 ± 0.0058 | 0.077 ± 0.021 | [5.1] | 0.43 ± 0.32 | [29] | 0.17 ± 0.20 | [11] |
DS-5000 | 0.60 ± 0.17 | 0.50 ± 0.26 | [0.8] | 0.60 ± 0.35 | [1] | 0.21 ± 0.17 | [0.35] |
AMD3100 | 0.031 ± 0.020 | 0.057 ± 0.006 | [1.8] | 0.025 ± 0.013 | [0.8] | 0.10 ± 0.09 | [3.2] |
T-20 | 0.038 ± 0.010 | 0.047 ± 0.014 | [1.2] | 0.036 ± 0.026 | [1.0] | 0.053 ± 0.015 | [1.4] |
UC-781 | 0.0015 ± 0.0004 | 0.002 ± 0.0003 | [1.3] | 0.003 ± 0.0004 | [2.0] | 0.003 ± 0.0007 | [2.0] |
(R)-PMPA | 1.0 ± 0.25 | 1.3 ± 1.2 | [1.3] | 4.1 ± 2.8 | [4.1] | 2.8 ± 0.73 | [2.8] |
Mab 2G12 | 1.4 ± 0.4 | >25 | [>15] | >25 | [>15] | >25 | [>15] |