Comparison of IMDS and hαCGRP potency for stimulation of cAMP accumulation at human CT, AMY, CGRP, and AM receptors
Values are presented as mean ± S.E.M.
| Receptor | Agonist | pEC50 | n |
|---|---|---|---|
| CT(a) | IMDS | 6.53 ± 0.09 | 6 |
| hαCGRP | 6.80 ± 0.04 | 5 | |
| AMY1(a) | IMDS | 8.07 ± 0.19* | 6 |
| hαCGRP | 8.70 ± 0.17 | 10 | |
| AMY2(a) | IMDS | 6.25 ± 0.26 | 6 |
| hαCGRP | 7.24 ± 0.19 | 5 | |
| AMY3(a) | IMDS | 7.12 ± 0.19† | 6 |
| hαCGRP | 7.60 ± 0.17 | 6 | |
| CGRP1 | IMDS | 8.71 ± 0.13 | 8 |
| hαCGRP | 9.47 ± 0.19 | 6 | |
| AM1 | IMDS | 8.10 ± 0.04 | 4 |
| hαCGRP | 6.39 ± 0.10 | 4 | |
| AM2 | IMDS | 8.69 ± 0.13 | 5 |
| hαCGRP | 6.87 ± 0.13 | 3 |