TABLE 3

Association of 5′-untranslated and exon polymorphisms of the UGT1A7 gene

Genotyping analyses by Taqman allelic discrimination PCR of the 5′-untranslated SNP, N129K/R131K, and W208R variants of the UGT1A7 gene first exon indicate a linkage dysequilibrium of the 5′-untranslated located UGT1A7 –57 G SNP and the exon 1 located Arg208 SNP. Arg208 was always present when the UGT1A7 –57 G was detected. On the other hand, UGT1A7 –57 T was always simultaneously present with Trp208. A similar linkage dysequilibrium was not found for N129K/R131K and –57 T/G, although homozygous carriers of UGT1A7 –57 G were also homozygous for the UGT1A7 Lys129/Lys131 in all but one person.