Artemisinin induces P450 and MDR1 expression in human hepatocytes
Induction of mRNA expression by treatment with 30 μM rifampin (RIF) or 300 μM artemisinin (ART) in primary human hepatocytes derived from four donors. Data represent fold induction relative to treatment with vehicle Me2SO alone.
| Gene | Donor BH-01 | Donor BH-02 | Donor BH-03 | Donor BH-04 | ||||
|---|---|---|---|---|---|---|---|---|
| RIF | ART | RIF | ART | RIF | ART | RIF | ART | |
| CYP2B6 | 15.8 | 17.3 | 5.1 | 7.2 | 15.8 | 16.2 | 6.3 | 15.2 |
| CYP2C19 | 1.2 | 0.8 | 0.8 | 0.4 | 10.2 | 4.6 | 9.3 | 2.1 |
| CYP3A4 | 50.3 | 36.9 | 15.6 | 10.9 | 179.5 | 30.2 | 16.4 | 5.3 |
| MDR1 | 3.9 | 5.1 | 1.5 | 0.6 | 4.8 | 2.7 | 3.0 | 3.4 |