Upregulated Gene/mRNA | Mean-Fold Change | Cellular Roles | |||
---|---|---|---|---|---|
Gqα | Range | G14α | Range | ||
Surface receptors/ligands/signaling proteins | |||||
Urokinase/plasminogen receptor (uPAR-1) | 7.2 | 6.9-7.5 | 8.2 | 8.2-8.3 | Cell-surface tPA receptor; TNFα-induced |
Bone morphogenic protein 2 (BMP-2) | 6.3 | 4.1-8.4 | 6.0 | 3.0-8.9 | TGF-β-like peptide; TNFα-induced |
Follistatin (Fst; FOL1) | 6.1 | 5.5-6.7 | 4.0 | 4.0-4.1I | Inhibits FSH release |
B-type natriuretic factor (BNF) | 5.7 | 4.7-6.7 | 4.5 | 3.7-5.2 | Vasoactive peptide |
LDL-receptor 1, oxidized (Orl1; LOX-1) | 4.0 | 2.9-5.0 | 3.3 | 3.1-3.4 | Lectin/lipoprotein receptor; TNFα-induced |
Anti-proliferative, B-cell translocation gene 2 (BTG-2; Tis21; PC3) | 3.4 | 3.0-3.7 | 3.5 | 2.6-4.3 | p53 effector; blocks proliferation |
Vascular endothelial growth factor A 110 (VEGF) | 2.9 | 2.5-3.3 | 2.9 | 2.5-3.3 | Mitogen, primarily for vascular endothelial cells |
Osteoclast inhibitory lectin (Ocil) | 2.6 | 2.5-2.6 | 2.4 | 2.4-2.4 | TM protein; binds lectins; killer cells |
Transporters/channels | |||||
Multi-drug resistance gene (Mdr1a) | 7.8 | 3.7-11.9 | 5.6 | 3.7-7.5 | ABC transporter, drug efflux; TNFα-induced |
Gap junction membrane channel α4 (Connexin37) | 5.5 | 4.0-7.0 | 4.7 | 3.5-5.8 | Component of gap junctions; TNFα-induced |
Monocarboxylate transporter (Mct3) | 3.6 | 3.0-4.3 | 3.2 | 2.8-3.6 | PM transporter for pyruvate and lactate |
Kinases/phosphatases | |||||
MAP-kinase phosphatase (Cpg21) | 6.2 | 5.4-7.0 | 7.4 | 6.8-8.0 | Dual specificity phosphatase for Erk1 |
Serum/glucocorticoid regulated kinase (Sgk) | 4.9 | 4.8-5.0 | 3.7 | 3.7-3.9 | Dual spec. phosphatase; regulates ion channels |
MAPKinase kinase kinase 8 (Map3K8;Tpl2;Cot) | 4.7 | 3.5-6.0 | 2.8 | 2.4-3.3 | Ser/Thr kinase for JNK; regs TNFα synthesis |
Hexokinase 2 (Hk2) | 4.0 | 3.2-4.8 | 3.8 | 3.6-4.0 | Phosphorylates glucose to glucose-6-phosphate |
Protein tyrosine phosphatase | 3.9 | 3.7-4.1 | 3.0 | 2.7-3.3 | Dual-specific phosphatase for MAPkinases |
Pyruvate dehydrogenase kinase 1 (Pdk1) | 3.4 | 3.4-3.5 | 2.7 | 2.5-2.8 | Inactivates PDH; terminates pyruvate decarboxyl |
Sphingosine kinase 1c (Sphk1c) | 2.4 | 2.2-2.7 | 2.4 | 2.2-2.5 | Phosphorylates sphingosine; proliferation |
Transcription factors and modulators | |||||
Activating transcription factor (Atf3/LRF1) | 7.8 | 7.4-8.4 | 5.3 | 4.8-5.8 | CREB-like transcription factor; TNFα-induced |
NGF-induced transcription factor (NGFI-B;Nurr77) | 5.3 | 2.7-7.8 | 3.3 | 2.0-4.6 | Transcription factor; mediates TNFα actions |
Gonadotropin inducible ovarian transcription factor-1 (Giot1) | 4.2 | 4.1-4.3 | 2.2 | 2.2-2.3 | Transcriptional repressor, gonadotropin-induced |
cAMP responsive element modulator (CREM) | 3.0 | 2.7-3.3 | 2.5 | 2.2-2.8 | cAMP regulated transcriptional modulator |
Rat nuclear receptor (RNR-1) | 3.6 | 2.7-4.5 | 2.4 | 2.0-2.8 | Transcription factor |
Nuclear factor Nfil3/E4BP4 | 2.3 | 2.3-2.5 | 2.3 | 2.2-2.4 | Leucine zipper transcription factor |
Extracellular matrix | |||||
TNF-α stimulated gene 6 (TSG-6) | 12.1 | 6.2-17.9 | 12.7 | 7.1-18.2 | Binds hyaluronan, arthritis; TNFα-induced |
Hyaluronan synthase 2 (Has2) | 4.8 | 3.1-6.4 | 5.4 | 2.9-7.9 | Produces extracellular hyaluronan; TNFα-induced |
UDP galactose-4-epimerase (GALE) | 2.3 | 2.1-2.5 | 2.4 | 2.4-2.4 | Epimerization of UDP-glycoproteins, glycolipids |
Disintegrin and metalloprotease (ADAMTS-1) | 2.9 | 2.8-3.0 | 2.4 | 2.3-2.5 | Cleavage of extracellular proteoglycans |
Membrane proteoglycan (NG2) | 2.7 | 2.4-3.0 | 2.2 | 2.2-2.3 | Proteoglycan |
Metabolism and other | |||||
Calponin 1 (CaP; Cnn) | 3.5 | 3.3-3.6 | 3.1 | 2.6-3.6 | Smooth muscle contraction; TNFα regulated |
Annexin A3 (Anx3; Lipocortin 3) | 3.2 | 2.8-3.5 | 2.6 | 2.3-2.8 | Membrane trafficking/fusion |
Adenoviral interacting protein 3 (Bnip3) | 3.2 | 2.8-3.5 | 2.6 | 2.3-2.8 | BCL2-binding, pro-apoptotic |
UDP-glucuronosyltransferase | 3.2 | 2.6-3.8 | 3.3 | 2.6-4.1 | |
T cell death-associated gene (Tdag) | 2.9 | 2.4-3.5 | 3.1 | 2.5-3.7 | Inhibits protein synthesis; apoptotic |
α-Crystallin (Hsp22) | 2.8 | 2.4-3.1 | 2.1 | 2.1-2.1 | Stress-inducible chaperonin; induces TNFa |
UDP-glucuronosyltransferase 1A7 (UGT1A7) | 2.8 | 2.4-3.2 | 2.7 | 2.2-3.2 | Metabolism of endo- and xenobiotics |
Antizyme inhibitor | 2.8 | 2.8-2.8 | 2.1 | 2.0-2.2 | Inhibits ODC antizyme |
Neurominadase 1 (Neu1) | 2.2 | 2.2-2.2 | 2.2 | 2.2-2.2 | Modifies glycoproteins and glycolipids |
a Listed are defined annotated genes (38) of 137 total that changed.