Defined genes down-regulated by Gqα and G14α, but not by G15α, in VSMC
Bold indicates genes with reported roles in apoptosis and/or TNFα signaling (see text). Listed are defined annotated genes (11) of 85 total that changed.
| Down-Regulated Gene/mRNA | Mean -Fold Change | Cellular Roles | |||
|---|---|---|---|---|---|
| Gqα | Range | G14α | Range | ||
| Surface receptors/ligands/signaling proteins | |||||
| Angiotensin II receptor. Type 1A (AT1A) | -6.0 | -4.9,-7.0 | -5.7 | -5.2,-6.2 | Receptor (GPCR) for angiotensin II |
| Growth factor receptor binding protein 14 (Grb14) | -3.9 | -3.8,-4.0 | -3.3 | -3.3,-3.3 | Tyr Kinase receptor adaptor protein |
| Vasopressin receptor 1A (AVPR1a) | -3.6 | -3.3,-3.9 | -3.2 | -3.1,-3.4 | Receptor (GPCR) for vasopressin |
| Potassium channel, tandem pore (TREK-1, KCNK2) | -2.6 | -2.4,-2.8 | -2.4 | -2.0,-2.7 | “Leak” potassium channel |
| Fractaline (Cx3cl1) | -2.7 | -2.2,-3.2 | -2.2 | -2.0,-2.6 | Inducible cytokine; reg by TNFa |
| Nuclear transcription factors/modulators | |||||
| Cardiac adriamycin responsive protein (CARP) | -3.5 | -3.4,-3.6 | -2.7 | -2.0,-3.4 | Nuclear transcription factor |
| Mesenchyme homeobox 2 protein (Meox2) | -2.8 | -2.1,-3.5 | -2.6 | -2.1,-3.2 | Nuclear homeobox transcription factor |
| Butyrate response factor (Brf1) | -2.5 | -2.1,-2.8 | -2.3 | -2.1,-2.6 | Immediate early, transcription factor |
| Signal transducer/activator transcription 1 (Stat1) | -2.4 | -2.4,-2.4 | -2.5 | -2.0,-3.0 | Transcription factor; reg by TNFa |
| Other | |||||
| Guanylate binding protein 2, INF-inducible (Gbp2) | -3.4 | -3.2,-3.5 | -3.1 | -3.1,-3.2 | INF-induced GTPase, undefined |
| Microsomal glutathione-S transferase (Mgst1) | -3.3 | -2.8,-3.8 | -3.0 | -2.8,-3.3 | Protection from oxidative stress |