TABLE 1
Mean peak tail IKCNH2 values for cells expressing WT KCNH2 and Class 2 LQT2 channel proteins
Peak tail IKCNH2 was measured in cells transiently expressing the WT KCNH2, G601S, F640V, or N470D channel proteins. The percentage reduction in the mean peak tail IKCNH2 for cells expressing the G601S, F640V, or N470D channel proteins compared with cells expressing WT KNCH2 channel proteins is given. Peak tail IKCNH2 was measured in cells transiently expressing the Y652C substitution, G601S/Y652C, F640V/Y652C, or N470D/Y652C channel proteins. The percentage reduction in the mean peak tail IKCNH2 for cells expressing the G601S/Y652C, F640V/Y652C, or N470D/Y652C channel proteins compared with cells expressing Y652C channel proteins is given.